Austin N. Hoang

This study uses nanopore sequencing to show that mtDNA deletion mutations increase exponentially with age and map to a wider genomic region, with novel algorithms improving detection accuracy.

This study investigates the effects of remdesivir on mitochondrial DNA in aged rats and finds no significant changes in copy number or deletion mutation frequency.

This paper introduces a method to sequence mtDNA using Cas9-guided adaptor ligation and nanopore long reads, enabling mutation phasing and detection of age-induced deletions in a patient with mtDNA-linked syndrome.