Hermann M. Schätzl

This study investigates the distinct roles of Hsp110 proteins in mammalian prion propagation using CRISPR knockouts and shows varying effects on PrPSc accumulation and seeding activity.

This study shows that vaccination reduces prion shedding in feces and urine of CWD-infected mice, potentially breaking the transmission cycle.

This study shows CWD prions can infect humanized mice, leading to atypical symptoms and transmissible infectivity, suggesting zoonotic potential and possible human transmission.

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.