Carsten Werner

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

This study shows that cancer cells adjust their nuclear volumes and proliferation rates during transitions between single and multicellular states in tumor spheroids.

This paper develops scalable fabrication of anisotropic polymeric microfibers for 3D tissue models, showing they guide cell growth in high-throughput systems.

This study characterizes hydrogel viscoelasticity at micro- and macro-scales using AFM and finite element modeling, developing a model with <5% error for parameter prediction.

This study uses programmable hydrogels to reveal two mechano-sensing timescales in MDCK cells and shows how dynamic mechanical cues influence cell polarity and morphogenesis.

This study shows that mechanical properties and YAP/TAZ activity influence position-dependent cell proliferation during axolotl limb regeneration.

The paper shows that Ngfr promotes neurogenesis and reduces amyloid pathology in AD mouse models by suppressing Lcn2/Slc22a17 signaling.

This paper investigates whether demyelination in multiple sclerosis leads to selective neurodegeneration of inhibitory interneurons and presents a rodent model to study this phenomenon.

This study shows that IL4 restores neurogenic plasticity of human NSCs by suppressing KAT2, which is upregulated in AD mouse models.

This paper introduces a 3D hydrogel culture system to model human neural stem cell plasticity, neurogenesis, and neurodegeneration, showing improved neuronal maturation and disease modeling.