Author

Niklas Rindtorff

German Cancer Research CenterORCID 0000-0003-3602-4170Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Erica ValentiniiD· 3 shared Michael BoutrosiD· 3 shared Elke BurgermeisteriD· 2 shared Johannes BetgeiD· 2 shared Matthias P. EbertiD· 2 shared Sebastian BelleiD· 2 shared Thilo MierschiD· 2 shared Tianzuo ZhaniD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

Erica ValentiniORCID

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Author profile →

4 papers

Recent·Most cited

Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancer

Theresa Mulholland, Bogac Aybey, Zhenchong Li, Luisa E. Schwarzmüller, Niklas Rindtorff, Lucrezia Tondo, Ping Sui, Ekin Karabati, Philipp Albrecht, Julian E. Riedesser, Yvonne Petersen, Thilo Miersch, Erica Valentini, Elke Burgermeister, Tianzuo Zhan, , Johannes Betge

The paper identifies a fetal-like stem cell trajectory in colorectal cancer using multi-omics and organoid models, linked to poor prognosis and SRC/mTOR dependency.

bioRxiv · Jul 3, 2026 · PreprintCancer Biology

Restraining Wnt activation and intestinal tumorigenesis by a Rab35 dependent GTPase relay

Siamak Redhai, Tianyu Wang, Kim. E Boonekamp, Saskia Reuter, Tümay Capraz, Svenja Leible, Shivohum Bahaguna, Fillip Port, Bojana Pavlović, Michaela Holzem, Roman M. Doll, Niklas Rindtorff, Erica Valentini, Barbara Schmitt, Karsten Richter, , Michael Boutros

This study identifies Rab35 as a tumor suppressor that modulates Wnt signaling through a GTPase relay, highlighting its role in restraining intestinal tumorigenesis.

bioRxiv · Feb 5, 2024 · PreprintCancer Biology

A dual MTOR/NAD+ acting gerotherapy

Jinmei Li, Sandeep Kumar, Kirill Miachin, Nicholas L. Bean, Ornella Halawi, Scott M. Lee, Jiwoong Park, Tanya Hans Pierre, Jin‐Hui Hor, Shi‐Yan Ng, K. Wallace, Niklas Rindtorff, Timothy M. Miller, Michael L. Niehoff, Susan A. Farr, , Timothy R. Peterson

This paper identifies BIOIO-1001 as a dual mTOR/NAD+ acting gerotherapy that reduces metabolic derangements, inflammation, and fibrosis in NASH and ALS models.

bioRxiv · Jan 16, 2023 · PreprintGenomics

The drug-induced phenotypic landscape of colorectal cancer organoids

Johannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini, Kim E. Boonekamp, Veronika Hauber, Tobias Gutting, Larissa Frank, Sebastian Belle, , Michael Boutros

This study uses image-based profiling and multi-omics integration to identify morphological axes of variation in colorectal cancer organoids and link them to biological mechanisms and drug responses.

Nature Communications · Jun 6, 2022Peer-reviewedGenomics