Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet‐Coello, Sébastien Herzig, Marc Foretz, Benoı̂t Viollet, Reuben J. Shaw, Andrew A. Sproul, Franck Polleux
This study shows Aβ42 oligomers cause synaptic loss by activating CAMKK2-AMPK, which coordinates mitochondrial fission and mitophagy in neurons.
Nature Communications · Aug 1, 2022Peer-reviewedNeuroscience