Tommy L. Lewis

This study shows that MLKL in hepatocytes promotes liver aging by inducing senescence and mitochondrial dysfunction without causing necroptosis.

This study uses in vivo 2-photon imaging and photoactivatable fluorescent labeling to show that mitochondrial dynamics in skeletal muscle are slower in vivo than previously thought, with age-related differences and exercise-induced increases.

This study shows Fis1 depletion reduces dendritic mitochondrial length and alters mitochondrial function, leading to increased calcium levels and changes in dendritic branching and spine density.

This study shows metformin induces different mitochondrial remodeling in rat skeletal muscle based on baseline aerobic capacity and muscle type.

The paper shows that most axonal mitochondria in mammalian neurons lack mtDNA and do not produce ATP, contrasting with dendritic mitochondria.

This study identifies fixation and oxygen levels during perfusion as critical factors affecting neuronal mitochondrial morphology in vitro and in vivo.

This study shows Aβ42 oligomers cause synaptic loss by activating CAMKK2-AMPK, which coordinates mitochondrial fission and mitophagy in neurons.

The paper shows how Siah2 and Pard3/JamC modulate Ntn1 signaling via Dcc to control GZ exit of cerebellar granule neurons.

This study shows that necroptosis increases with age in the brain and contributes to age-related neuroinflammation in mice.

This study shows that haploinsufficiency of the autism candidate gene Nuak1 in mice causes cortical development defects and behavioral abnormalities resembling ASD, intellectual disability, and schizophrenia.