Author

Luke Gaughan

Newcastle UniversityORCID 0000-0002-9330-7874Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

Adriana BuskiniD· 3 shared Anastasia C. HepburniD· 3 shared Craig N. RobsoniD· 3 shared Rakesh HeeriD· 3 shared Emma ScottiD· 2 shared Laura WilsoniD· 2 shared Ryan NelsoniD· 2 shared Simon W. HaywardiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCell Biology

Adriana BuskinORCID

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3 papers

Recent·Most cited

Cell BiologyCell Reports MethodsPeer-reviewedJul 29, 2026

Xeno-free human iPSC-derived prostate organoid platform for multilineage differentiation and genetic manipulation

Neha Shaikh, Matthew D. Teasdale, Lewis J. Walker…·Adriana Buskin

This paper develops a xeno-free human iPSC-derived prostate organoid platform that enables multilineage differentiation and genetic manipulation for studying prostate biology and disease.

DOI 10.1016/j.crmeth.2026.101538

humanorganoid / primary culture

Cancer BiologybioRxivPreprintOct 15, 2025

The Androgen Receptor and MYC synergise to modulate the synthesis of Siglec-7 ligands in prostate cancer

Adam Duxfield, Rebecca Garnham, Esme Hutton…·Emma Scott

This study shows that the androgen receptor and MYC work together to control the production of Siglec-7 ligands in prostate cancer by regulating sialylation and glycopeptide profiles.

1 citation

humanproteomics

Developmental BiologyStem Cells Translational MedicinePeer-reviewedMar 14, 2020

High-throughput propagation of human prostate tissue from induced-pluripotent stem cells

Anastasia C. Hepburn, Emma L. Curry, Mohammad Moad…·Rakesh Heer

This paper introduces a high-throughput method to generate human prostate tissue from induced pluripotent stem cells using co-culture with urogenital sinus mesenchyme.

37 citations

humanexperimental assay