Rakesh Heer

The paper reports mutation rates and mutational signatures across 53 normal human cell types, revealing variation in mutation accumulation and identifying known and unknown mutational processes.

This paper develops a xeno-free human iPSC-derived prostate organoid platform that enables multilineage differentiation and genetic manipulation for studying prostate biology and disease.

This study shows that the androgen receptor and MYC work together to control the production of Siglec-7 ligands in prostate cancer by regulating sialylation and glycopeptide profiles.

This study identifies Arid1a loss as a driver of aggressive prostate cancer in mice, accelerating tumorigenesis and promoting a proliferative, collagen-poor phenotype through cooperation with cFos.

The paper establishes international consensus criteria to classify ageing-related pathologies, diseases, and syndromes based on age progression, functional decline, and human evidence.

This study compares mutational landscapes in somatic and germline cells across 29 anatomical structures, identifying key mutational signatures and their contributions to different cell types.

This paper introduces a high-throughput method to generate human prostate tissue from induced pluripotent stem cells using co-culture with urogenital sinus mesenchyme.