Cian O’Donnell

This study proposes a computational model explaining length-dependent protein synthesis during synaptic plasticity, showing it results from a shift in ribosomal regulation mechanisms.

The paper examines region- and layer-specific glutamatergic synapse maturation in the developing cortex, finding that layers involved in higher-order circuits mature later, particularly in layer 1 during adolescence.

The paper shows that non-random brain connectome wiring improves robustness and efficiency in sparse neural networks compared to random wiring.

The paper applies hierarchical Bayesian modeling to multi-region brain cell count data, showing improved inference over traditional methods in under-sampled datasets.

The paper models pre-miRNA competition for Dicer and validates it using in vitro and ex vivo data, showing that efficient Dicer interaction and TRBP association influence mature miRNA levels.

The paper uses deep learning to measure representational drift in neural recordings and finds that rewarded experiences better predict drift than time or session count.

This paper introduces a stochastic model of hippocampal synaptic plasticity that maps enzyme dynamics to plasticity outcomes, successfully reproducing nine ex vivo experiments.

The paper builds a biophysical model to show how spine neck plasticity regulates long-term potentiation by controlling AMPAR and calcineurin dynamics.

The paper analyzes neural population data from mice to show that neural ensembles are localized at fast timescales but span multiple regions at slower timescales, suggesting fast-local and slow-global computations.

This study shows that reduced DLG2 expression in rats impairs hippocampal synaptic integration and plasticity, which can be reversed by muscarinic M1 receptor agonists.

The paper uses a computational model of CA3 pyramidal neurons to show acetylcholine enhances dendritic excitability and reduces the number of synapses needed to generate NMDA spikes.

This study investigates how dopamine affects memory consolidation during sleep, finding that it enhances forgetting of weak memories and increases slow wave sleep duration.

The paper tests the E/I imbalance model in Fragile X syndrome using computational modeling and 2-photon imaging data, finding it insufficient and revealing stage-dependent circuit changes.