Author

Sarah Bigot

Lyon 1 UniversitéORCID 0000-0002-9340-6303Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christian LesterliniD· 3 shared Annick Berne-DedieuiD· 2 shared Yannick Baffert· 2 shared Adeline PageiD· 1 shared Allison J. LopatkiniD· 1 shared Bogdan Iuliu IorgaiD· 1 shared Chloé VirolleiD· 1 shared Daouda A. K. TraoréiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMicrobiology

Christian LesterlinORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 1, 2026

Model-based evaluation of Targeted-Antibacterial-Plasmids (TAPs) transfer kinetics and resensitization of pOXA-48 carbapenem-resistant Escherichia coli

Sophie Marolleau, Jérémy Moreau, Julien M. Buyck…·Vincent Aranzana‐Climent

The paper evaluates TAPs transfer kinetics and resensitization efficiency in E. coli using a mechanistic model of subpopulation dynamics, finding plasmid delivery is the main bottleneck.

DOI 10.64898/2026.09.01.748484

E. colistatistical model

𝕏 PostBluesky

MicrobiologybioRxivPreprintJul 7, 2026

Plasmid-encoded host reprogramming promotes plasmid dissemination

Chloé Virolle, Sibylle Ferrarin, Gaël Panis…·Christian Lesterlin

The paper identifies YfjB as a host reprogramming factor that enables plasmid dissemination by altering host transcription and metabolism.

DOI 10.64898/2026.07.07.736705

ChIP-seqstructural biology

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MicrobiologyNature CommunicationsPeer-reviewedAug 19, 2025

Genetic Determinants of pOXA-48 Plasmid Maintenance and Propagation in Escherichia coli

Yannick Baffert, Nathan Fraikin, Yasmine Makhloufi…·Sarah Bigot

This study identifies genetic elements critical for pOXA-48 plasmid stability, replication, and conjugative transfer using transposon sequencing.

10 citations

E. coliexperimental assay

𝕏 PostBluesky