Christian Lesterlin

RecA structure kinetics determine SOS dynamics and predict spontaneous cell death

The paper shows RecA* structure dynamics predict spontaneous cell death in E. coli by linking SOS response magnitude to DNA repair kinetics.

Antibiotic inhibition uncouples growth from horizontal gene transfer

This study shows that different antibiotics create distinct plasmid transfer dynamics, revealing drug-specific residual conjugation windows that are decoupled from growth inhibition.

Model-based evaluation of Targeted-Antibacterial-Plasmids (TAPs) transfer kinetics and resensitization of pOXA-48 carbapenem-resistant Escherichia coli

The paper evaluates TAPs transfer kinetics and resensitization efficiency in E. coli using a mechanistic model of subpopulation dynamics, finding plasmid delivery is the main bottleneck.

Plasmid-encoded host reprogramming promotes plasmid dissemination

The paper identifies YfjB as a host reprogramming factor that enables plasmid dissemination by altering host transcription and metabolism.

Widespread immune systems protect bacteria against conjugative plasmids

This study identifies three novel immune systems in bacteria that protect against conjugative plasmids, revealing their role in limiting plasmid spread and highlighting the evolutionary arms race between bacteria and plasmids.

Coupling DNA processing to early gene expression drives antibiotic resistance plasmid dissemination

This study shows conjugative plasmids delay DNA synthesis to prolong early gene expression, enhancing survival in new hosts and promoting antibiotic resistance dissemination.

Exclusion Systems Preserve Host Cell Homeostasis and fitness, Ensuring Successful Dissemination of Conjugative Plasmids and Associated Resistance Genes

The paper shows exclusion systems in plasmids prevent uncontrolled transfer, maintaining host cell fitness and enabling plasmid spread.

Genetic Determinants of pOXA-48 Plasmid Maintenance and Propagation in Escherichia coli

This study identifies genetic elements critical for pOXA-48 plasmid stability, replication, and conjugative transfer using transposon sequencing.

A palette of bright and photostable monomeric fluorescent proteins for bacterial time-lapse imaging

The paper introduces four new monomeric fluorescent proteins for bacterial time-lapse imaging, showing improved photostability, brightness, and monomericity compared to existing standards.