Nourhan El Ahmar

Pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology

This paper introduces TIME_ACT, a transcriptomic signature predicting immune checkpoint blockade response across cancers, validated using histopathology and multiple cohorts.

PASTA: Versatile Tyramine-oligonucleotide Amplification for Multi-modal Spatial Biology

PASTA enhances spatial biology detection sensitivity while maintaining compatibility with multiple modalities and multiplexing strategies.

Same-Slide Spatial Multi-Omics Integration Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment

This paper introduces IN-DEPTH and SGCC for spatial multi-omics analysis, revealing EBV-related immunomodulatory differences in DLBCL.

Epigenomic signatures as circulating and predictive biomarkers in sarcomatoid renal cell carcinoma

The paper identifies epigenomic signatures in sarcomatoid renal cell carcinoma (sRCC) that predict response to immune checkpoint inhibitors and are detectable in plasma, enabling non-invasive diagnosis.