Author

Kathryn J. Isaac

Johns Hopkins UniversityORCID 0000-0002-9374-031XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:ChIP-seq· 2 Research Focus:database / resource· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Approach:benchmark study· 1

Frequent Co-Authors

Alexander Q. WixomiD· 2 shared Amber Miller· 2 shared April Cockburn· 2 shared Belinda M. GiardineiD· 2 shared Berthold GöttgensiD· 2 shared Cheryl A. KelleriD· 2 shared David M. BodineiD· 2 shared Douglas R. HiggsiD· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Alexander Q. WixomORCID

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Author profile →

4 papers

Recent·Most cited

Insights into the Datasets, Tools, and Training Needs of the AnVIL Community: 2024

Kathryn J. Isaac, Katherine E.L. Cox, Kai Yin Ho, Elizabeth Humphries, Natalie Kucher, Jeffrey T. Leek, Stephen Mosher, Michael C. Schatz, Frederick J. Tan, Ava M. Hoffman

This study surveys the AnVIL community to understand user needs, training preferences, and platform adoption opportunities.

F1000Research · Dec 22, 2025Peer-reviewedScientific Communication & Education

Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes

Guanjue Xiang, Xi He, Belinda M. Giardine, Kathryn J. Isaac, Dylan J. Taylor, Rajiv C. McCoy, Camden S. Jansen, Cheryl A. Keller, Alexander Q. Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, , Ross C. Hardison

This study identifies conserved and species-specific cis-regulatory elements in human and mouse blood cells using integrative epigenomic analysis and clustering.

Genome Research · Jul 1, 2024Peer-reviewedGenomics

Strict adherence to Mendel's First Law across a large sample of human sperm genomes

Sara A. Carioscia, Kathryn J. Isaac, Andrew N. Bortvin, Hao Pan, Daniel Ariad, Avery Davis Bell, Rajiv C. McCoy

The paper analyzes human sperm genomes to test for transmission distortion, finding no evidence of weak TD and introducing a new method for low-coverage data.

eLife · Dec 7, 2022Peer-reviewedGenomics

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis

Guanjue Xiang, Cheryl A. Keller, Elisabeth F. Heuston, Belinda M. Giardine, Lin An, Alexander Q. Wixom, Amber Miller, April Cockburn, Michael E.G. Sauria, Kathryn J. Isaac, Jens Lichtenberg, Berthold Göttgens, Qunhua Li, David M. Bodine, Shaun Mahony, , Ross C. Hardison

The paper integrates epigenomic and transcriptomic data from mouse hematopoiesis to identify regulatory elements and their dynamics across cell types.

Genome Research · Mar 1, 2020Peer-reviewedGenomics