Probing mechanical selection in diverse eukaryotic genomes through accurate prediction of 3D DNA mechanics
Jonghan Park, Galina Prokopchuk, Andrew R. Popchock, Jingzhou Hao, Ting-Wei Liao, S. Betty Yan, Dylan J. Hedman, Joshua Donald Larson, Brandon K. Walther, Nicole A. Becker, Aakash Basu, Louis James Maher III, Richard John Wheeler, Charles L. Asbury, Sue Biggins, , Taekjip Ha
This paper develops a computational model to predict DNA mechanics from sequence, revealing mechanical selection in diverse eukaryotes and identifying extreme DNA mechanics in nature.
bioRxiv · Dec 22, 2024 · PreprintBiophysics