Andrew R. Popchock

This study directly observes the sequential and interdependent assembly of kinetochores on individual centromeres in budding yeast, revealing regulatory dependencies and a rate-limiting step in the process.

This study identifies TinA as an activator of KlpA, enabling minus-end-directed motility through direct interaction and structural modulation.

The paper investigates how the N-terminal domain of Cse4 stabilizes its association with centromeres in yeast, showing that OA and Scm3 independently stabilize Cse4 through their interactions with the END region.

This paper develops a computational model to predict DNA mechanics from sequence, revealing mechanical selection in diverse eukaryotes and identifying extreme DNA mechanics in nature.

The paper shows that kinetochores grip microtubules six-fold stronger when pulled toward plus ends, suggesting directional asymmetry in attachment strength contributes to mitotic accuracy.