Charles L. Asbury

This study shows that Cnn1 stabilizes kinetochore-microtubule attachments by enabling Stu2-dependent reinforcement, as demonstrated through in vitro assays and genetic experiments.

This study directly observes the sequential and interdependent assembly of kinetochores on individual centromeres in budding yeast, revealing regulatory dependencies and a rate-limiting step in the process.

This study shows that K. marxianus has a single centromeric nucleosome that mediates attachment to one microtubule, similar to S. cerevisiae.

The paper shows that centromeric DNA sequences enhance force transmission through the inner kinetochore via the Okp1/Ame1 complex.

The paper investigates how the N-terminal domain of Cse4 stabilizes its association with centromeres in yeast, showing that OA and Scm3 independently stabilize Cse4 through their interactions with the END region.

This paper develops a computational model to predict DNA mechanics from sequence, revealing mechanical selection in diverse eukaryotes and identifying extreme DNA mechanics in nature.

The paper shows that kinetochores grip microtubules six-fold stronger when pulled toward plus ends, suggesting directional asymmetry in attachment strength contributes to mitotic accuracy.

This study reveals the architecture and flexibility of native kinetochores using structural analyses of purified kinetochores from thermophilic yeast.

The paper shows that missense mutations in kinetochore proteins reduce chromosome instability in histone-humanized yeast by weakening microtubule attachments, promoting euploidy.

This study identifies a Stu2-mediated tension-sensing pathway that works with Aurora B to correct kinetochore attachments in vivo.