Piotr Drączkowski

This study uses GlycoSHIELD modeling and DNA-PAINT SMLM to show that N-glycosylation promotes Na,K-ATPase clustering by forming a steric shield, supporting a galectin-lattice organization mechanism.

The paper reports cryo-EM structures of the human 26S proteasome bound to K11/K48-branched ubiquitin chains, revealing a multivalent recognition mechanism involving new binding sites for K11 and alternating K11-K48 linkages.