Kuen‐Phon Wu

An AI agent supervised structural model building and refinement for cryo-EM and X-ray data, improving model quality with minimal researcher input.

This study compares low-magnification super-resolution and physical-pixel workflows in cryo-EM, showing that effectiveness depends on specimen-specific signal and sampling limitations.

This study investigates how calcium ions affect the structure and aggregation of the A53T mutant of α-synuclein, revealing structural changes in fibril formation.

The paper reports cryo-EM structures of the human 26S proteasome bound to K11/K48-branched ubiquitin chains, revealing a multivalent recognition mechanism involving new binding sites for K11 and alternating K11-K48 linkages.

The paper determines the cryo-EM structure of the UBA7-UBE2L6 disulfide complex and identifies factors influencing its formation, revealing its role in ISG15 conjugation and immune response regulation.

RE2DC improves 2D classification in cryo-EM by balancing computational efficiency and robustness, achieving faster processing and better resolution of rare particle populations.