Author

Ming-Chieh Tsai

Institute of Biological Chemistry, Academia Sinica

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Hsin-An ShihiD· 1 shared Jessica Y. C. Huang· 1 shared Kuen‐Phon WuiD· 1 shared Piotr DrączkowskiiD· 1 shared Rosa VineriD· 1 shared Shang‐Te Danny HsuiD· 1 shared Shu‐Yu LiniD· 1 shared Steven LiniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Hsin-An ShihORCID

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1 paper

Recent·Most cited

Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome

Piotr Drączkowski, Szu-Ni Chen, Ting Chen, Yong‐Sheng Wang, Hsin-An Shih, Jessica Y. C. Huang, Ming-Chieh Tsai, Shu‐Yu Lin, Steven Lin, Rosa Viner, Yuan‐Chih Chang, Kuen‐Phon Wu, Shang‐Te Danny Hsu

The paper reports cryo-EM structures of the human 26S proteasome bound to K11/K48-branched ubiquitin chains, revealing a multivalent recognition mechanism involving new binding sites for K11 and alternating K11-K48 linkages.

Nature Communications · Oct 15, 2025Peer-reviewedBiochemistry