Author

Nathan J. Coffey

Abramson Cancer CenterORCID 0000-0002-9413-5533Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Marie Celeste SimoniD· 2 shared Zoltan Pierre AranyiD· 2 shared Andy Zhao· 1 shared Boa KimiD· 1 shared Boyoung KimiD· 1 shared Brian Keith· 1 shared Caitlyn E. BowmaniD· 1 shared Cholsoon JangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Marie Celeste SimonORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 26, 2026

Hepatic urea cycle suppression drives brown fat thermogenesis to counter obesity and liver disease

Laura C. Kim, Nicholas P. Lesner, Xuanyan Cai…·Marie Celeste Simon

This study shows that reducing hepatic ASS1 protects against obesity and liver disease by enhancing brown fat thermogenesis.

DOI 10.64898/2026.06.02.729618

mouseexperimental assay

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Cancer BiologyJCI InsightPeer-reviewedOct 30, 2025

HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell Renal Cell Carcinoma

Wencao Zhao, Sara M. Demczyszyn, Nathan J. Coffey…·Boa Kim

This study shows HIF2α prevents GLS1 clustering in mitochondria, protecting ccRCC cells from glutamine deprivation, and suggests targeting GLS1 clustering could enhance HIF2 therapy.

3 citations

humanproteomics

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