Siôn Llewelyn Williams

This study identifies how epigenetic changes and spatial clustering influence immune dynamics and therapy resistance in melanoma through single-cell and spatial transcriptomics analyses.

This study shows miR-29a reprograms exhausted CD8 T cells into a stem-like state, enhancing their effector function and response to checkpoint inhibitors.

The paper integrates single-cell RNA sequencing data with drug response signatures to identify drug-sensitive and resistant glioblastoma cell states and predict synergistic drug combinations.