Alexandre Wojcinski

The paper integrates single-cell RNA sequencing data with drug response signatures to identify drug-sensitive and resistant glioblastoma cell states and predict synergistic drug combinations.

This paper develops a 3D brain vascular niche model to study GBM invasion and gene signatures, revealing glia-vascular contact influences transcriptional adaptation and poor prognosis.

This study identifies Plexin-B2 as a regulator of cell mechanics during multicellular organization, showing its role in modulating cell stiffness, contractility, and differentiation in human stem and progenitor cells.

The paper shows that reduction of cerebellar nuclei neurons leads to proportional scaling down of cerebellar cortex growth due to loss of their presynaptic Purkinje cells.

The paper shows that deleting GLI2 in cerebellar granule cell precursors does not cause severe cerebellar hypoplasia, as NEPs compensate by replenishing GCPs.

The paper shows that dormant progenitors regenerate Purkinje neurons after injury, but regenerative capacity declines with age.