Cancer BiologyNature CommunicationsPeer-reviewed
PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.
Joan Kyula, Victoria Roulstone, James Wright…·Kevin Joseph Harrington
This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.