Paul W. Frazel

Ancient Somatosensory Circuit Architectures Employ Flexible Molecular Strategies

This study shows that while spinal somatosensory circuit organization is conserved in skates, molecular programs specifying sensory neuron subtypes are distinct from mammals.

Mechanisms and control of a novel vocalization: the singing mouse song is a whistle that depends on air sac inflation

This study identifies the vocal mechanism of the singing mouse, revealing that its whistle-like song relies on air sac inflation and specific laryngeal muscles for frequency control.

Temporal and spatial analysis of astrocytes following stroke identifies novel drivers of reactivity

The paper analyzes astrocyte gene expression changes after stroke using spatial transcriptomics and single nucleus RNA-seq to identify novel reactive substates and their functional roles.

De novo assembly and annotation of the singing mouse genome

The paper assembles and annotates the genome of the singing mouse, using single nuclei sequencing to identify cell types in a brain region involved in song coordination.

Determinants of Motor Neuron Functional Subtypes Important for Locomotor Speed

The paper identifies molecular signatures and transcription factors that determine functional subtypes of motor neurons in zebrafish, showing their role in fast MN development.

Single-cell analysis of the nervous system at small and large scales with instant partitions

The paper benchmarks PIPseq, a single-cell RNA sequencing method, across different scales and models, showing its ability to detect cell types and differentially expressed genes.

Time series scRNAseq analysis in mouse and human informs optimization of rapid astrocyte differentiation protocols.

The paper uses scRNAseq data from mouse and human to identify candidate genes for glial fate specification and optimize astrocyte differentiation protocols.