Author

Gunhild Mechtersheimer

Institute of Pathology, Heidelberg University Hospital, Germany;ORCID 0000-0002-9442-3930Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Nischalan PillayiD· 2 shared Adarsh raveendran· 1 shared Adrienne Margaret FlanaganiD· 1 shared Akanksha Farswan· 1 shared Anna‐Christina Strobl· 1 shared Anushka DeshpandeiD· 1 shared Ashraf Yusuf RangreziD· 1 shared Christian KoelscheiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Nischalan PillayORCID

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2 papers

Recent·Most cited

EWSR1::ATF1 hyperactivation via TRIM11 depletion triggers lethal metabolic rewiring in clear cell sarcoma

Wenxin Chao, Kilian Bales, Kamini Kaushal, Laura Mayerhofer, Julien Picotto, Akanksha Farswan, Christopher Davies, Dawid Krzeciesa, Susanne Grunewald, Francisco Yanqui-Rivera, Nicola Biondi, Liang Chen, Adarsh raveendran, Anushka Deshpande, Kwang Seok Lee, , Priya Chudasama

This study identifies TRIM11 as a regulator of EWSR1::ATF1 stability in clear cell sarcoma, showing its depletion leads to metabolic rewiring and cell death, with PCK1 as a potential biomarker.

bioRxiv · Nov 10, 2026 · PreprintCancer Biology

Drivers underpinning the malignant transformation of giant cell tumour of bone

Matthew W. Fittall, Iben Lyskjær, Peter Ellery, Patrick Lombard, Jannat Ijaz, Anna‐Christina Strobl, Dahmane Oukrif, Maxime Tarabichi, Martin Sill, Christian Koelsche, Gunhild Mechtersheimer, Jonas Demeulemeester, Roberto Tirabosco, Fernanda M Amary, Peter J. Campbell, , Adrienne Margaret Flanagan

This study identifies genomic and methylation patterns associated with benign metastases and malignant transformation in giant cell tumour of bone.

The Journal of Pathology · Aug 31, 2020Peer-reviewedGenetic & Genomic Medicine