The Journal of PathologyGenetic & Genomic MedicinePeer-reviewed journal article
Drivers underpinning the malignant transformation of giant cell tumour of bone
Matthew W. FittalliD, Iben LyskjæriD, Peter ElleryiD, Patrick Lombard, Jannat IjaziD, Anna‐Christina Strobl, Dahmane OukrifiD, Maxime TarabichiiD, Martin SilliD, Christian KoelscheiD, Gunhild MechtersheimeriD, Jonas DemeulemeesteriD, Roberto TiraboscoiD, Fernanda M AmaryiD, Peter J. CampbelliD, Stefan Michael PfisteriD, David JonesiD, Nischalan PillayiD, Peter Van LooiD, Sam BehjatiiD, Adrienne Margaret FlanaganiD
Abstract
The rare benign giant cell tumour of bone (GCTB) is defined by an almost unique G34W oncohistone mutation in the H3.3 histone gene. Here we reveal the genomic and methylation patterns underlying the rare clinical phenomena of benign metastases and malignant transformation of GCTB.
- organism: human
- assay: DNA methylation
- assay: whole-genome sequencing
- research focus: differential expression
- research focus: gene regulatory network inference
- approach: statistical model
- Citations
- 35
- FWCI
- 3.96
- Field percentile
- top 5%
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