Sheng Xiao

The paper investigates how subthreshold membrane depolarization influences intracellular calcium dynamics in awake mice, showing strong coupling during prolonged depolarization and weaker coupling during isolated spikes.

The paper investigates how excitation and inhibition shape theta-gamma coupling in the medial entorhinal cortex using experimental and computational methods, revealing distinct cell-type contributions to oscillatory activity.

The paper analyzes the relative phase of membrane potential theta oscillations between hippocampal neurons during a virtual spatial task, revealing spatially coded phase shifts independent of spiking activity.

Ultrack improves cell tracking across 2D, 3D, and multi-channel time-lapse recordings by integrating multiple segmentations and temporal consistency, achieving state-of-the-art performance on benchmark datasets.

This paper introduces an oblique photothermal microscope (OPTM) for ultrasensitive in vivo IR spectroscopic imaging with sub-micron resolution, enabling low-dose imaging of skin and tracking of topical drugs.

This paper introduces a microscope combining targeted illumination and confocal gating to improve voltage imaging in dense tissues, enhancing signal-to-noise ratio and reducing crosstalk.

The paper shows that single and complex spikes in hippocampal neurons encode frequency-specific information during spatial navigation, with distinct roles for theta and gamma rhythms.

This paper demonstrates targeted illumination with SomArchon to enable large-scale voltage imaging in the brain, improving signal contrast and reducing background contamination.