Pascal Rihet

Identification and Functional Characterization of Regulatory Variants in DPP9 Associated with COVID-19 Severity

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

Unraveling a novel dual-function regulatory element showing epistatic interaction with a variant that escapes genome-wide association studies.

The paper identifies a dual-function regulatory element and a malaria risk variant that interact epistatically to influence T-cell activation and severe malaria susceptibility.

Identification of ATP2B4 regulatory element containing functional genetic variants associated with severe malaria

The paper identifies functional genetic variants in the ATP2B4 regulatory region associated with severe malaria and demonstrates their impact on gene expression and calcium homeostasis.

Transcriptional response in a sepsis mouse model reflects transcriptional response in sepsis patients

The paper compares the transcriptional response in a sepsis mouse model to human sepsis patients and identifies a shared molecular signature.