Christophe d’Enfert

The paper identifies the CCAAT-binding complex (CBC) as a key regulator that overrides genetic sterility in Candida albicans by integrating environmental stress signals to enable mating.

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

This paper studies how Candida albicans hyphae use helical growth and mechanical properties to navigate and invade surfaces, revealing a mechanical form of proprioception.

This study shows that altering BRG1 and CYR1 in a low-virulence C. albicans strain does not increase its virulence in vivo, suggesting complex gene networks regulate fungal pathogenicity.

This study identifies polygenic determinants of fluconazole susceptibility, tolerance, and heteroresistance in Candida albicans using GWAS on 557 isolates, revealing distinct genetic loci and mechanisms.

This study identifies beta-1,6-glucan as essential for fungal cell wall structure, integrity, and host-pathogen interactions.

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.

The paper generates an ORFeome collection and associated tools for studying Candida albicans pathogenesis.