The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

Genome Medicine · Jul 2, 2026Peer-reviewedGenetics

The Immune Factors Driving DNA Methylation Variation in Human Blood

Jacob Bergstedt, Sadoune Ait Kaci Azzou, Kristin Tsuo, Anthony Jaquaniello, Alejandra Urrutia, Maxime Rotival, David T S Lin, Julia L. MacIsaac, Michael Steffen Kobor, Matthew L. Albert, Darragh Duffy, Étienne Patin, Lluís Quintana‐Murci, Laurent Abel, Andrés Alcover, , Christophe Zimmer

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

Nature Communications · Oct 6, 2022Peer-reviewedGenomics

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes

Barthélémy Caron, Étienne Patin, Maxime Rotival, Bruno Charbit, Matthew L. Albert, Lluís Quintana‐Murci, Darragh Duffy, Antonio Rausell, Laurent Abel, Andrés Alcover, Hugues Aschard, Philippe Bousso, Nollaig M. Bourke, Petter Brodin, Pierre Bruhns, , Christophe Zimmer

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.

Genome Medicine · Mar 9, 2022Peer-reviewedGenetic & Genomic Medicine