Elena M. Ribé

The paper shows that synaptotoxic forms of amyloid-beta and alpha-synuclein act through the same Wnt/PCP pathway to cause dendritic spine loss in neurodegenerative diseases.

This study uses deep learning to profile neuronal morphology changes caused by Aβ1-42, achieving higher accuracy than traditional feature-based methods.

This study shows iPSC-derived astrocytes from AD patients reflect key pathophysiological features, offering a new model for AD research and therapeutic screening.

The paper uses induced pluripotent stem cell-derived cortical neurons from early Alzheimer's patients to show that cellular vulnerability to amyloid-beta correlates with clinical vulnerability.

This study shows fasudil reverses gene expression patterns associated with neurodegenerative disease in Alzheimer's model mice.

This study identifies shared transcriptomic changes between Alzheimer's disease and Major Depression in mice, suggesting Major Depression may be an early manifestation of Alzheimer's.

The paper combines GWAS, clinical data, and experimental models to identify JAK-STAT pathway dysregulation as a potential therapeutic target for Alzheimer’s disease.