PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer
Xiongjian Rao, Derek B. Allison, Robert M Flight, Penghui Lin, Daheng He, Zhiguo Li, Yanquan Zhang, Ruixin Wang, Chaohao Li, Jianlin Wang, Xinyi Wang, Jia Peng, Ka-wing Fong, Qing Shao, Chi Wang, , Xiaoqi Liu
The paper identifies PLK1-mediated phosphorylation of PHGDH as a mechanism driving serine metabolism reprogramming in advanced prostate cancer, increasing reliance on exogenous serine uptake.
Proceedings of the National Academy of Sciences · Jul 27, 2026Peer-reviewedCancer Biology