Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease
Zengjie Xia, Emily E. Prescott, Agnieszka N. Urbanek, Hollie E. Wareing, Marianne C. King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy Barnes, Martyna M. Matuszyk, Eleni Dimou, Eric Hidari, Yu P. Zhang, Jeff Y. L. Lam, John S. H. Danial, , Suman De
The paper shows that apoE isoforms modulate Aβ aggregation, clearance, and toxicity in Alzheimer's disease, with implications for therapeutic strategies.
Nature Communications · Jun 1, 2024Peer-reviewedNeuroscience