Ruoshi Yuan

Single-cell carbon storage dynamics drive conditional fitness in microbes

This study shows that carbon storage polymers like PHB provide a fitness advantage to microbes during environmental transitions by prolonging proliferation and aiding recovery from starvation.

Mapping Transcriptomic Vector Fields of Single Cells

The paper introduces dynamo, a framework for estimating RNA velocities and predicting cell fates using single-cell RNA-seq data, applied to various biological processes.

Towards a translationally-independent RNA-based synthetic oscillator using deactivated CRISPR-Cas

The paper constructs RNA-based synthetic oscillators using deactivated CRISPR-Cas systems in bacterial cells, finding that dCas12a oscillators perform better than dCas9 oscillators.

Systems Biology Theory Clarification of a Controversy in Pancreatic Beta Cell Regeneration

This paper reconciles conflicting evidence on pancreatic beta-cell regeneration by showing self-replicating beta-cells can act as multipotent precursors and predicting precursor differentiation paths.