Marco Y. Hein

Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq

This study uses Perturb-seq to functionally interrogate SARS-CoV-2 host factors in human lung epithelial cells, identifying key factors that influence infection and host response.

Mapping Transcriptomic Vector Fields of Single Cells

The paper introduces dynamo, a framework for estimating RNA velocities and predicting cell fates using single-cell RNA-seq data, applied to various biological processes.

Functional single-cell genomics of human cytomegalovirus infection

This study uses CRISPR screening and single-cell transcriptomics to analyze the functional roles of host and viral factors in HCMV infection, revealing distinct impacts on infection trajectories.

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

This study identifies the Hippo pathway's role in regulating sarcomeric gene expression to control myofibril assembly and muscle fiber growth in Drosophila.

MULTI-seq: Scalable sample multiplexing for single-cell RNA sequencing using lipid-tagged indices

The paper introduces MULTI-seq, a method for scalable sample multiplexing in scRNA-seq, enabling analysis of multiple tissues and perturbation experiments while improving data quality.