Sajad Hamid Ahanger

This study shows that H3.3K27M mutation disrupts lamina-associated domain organization, leading to activation of neuronal gene programs in DIPG.

Nucleotide GPT predicts nuclear subcompartment-associated genome architecture from DNA sequence using a transformer model, achieving high accuracy for lamina and speckle-associated domains.

The paper investigates the substructure and maturation of lamina-associated domains (LADs) in postmitotic neurons across human brain development, revealing dynamic changes in T1 and T2 LADs.

This study shows that spatial genome organization in human neurogenesis affects bivalent chromatin activity by relocating genes from the nuclear lamina to speckles, increasing transcription and resolving chromatin states.

This study shows that Kdm6b is essential for establishing and maintaining neural stem cells in the mouse hippocampus, with loss of Kdm6b leading to defective neurogenesis and cognitive impairments.