Eugene Gil

Disruption of lamina-associated genome organization activates neuronal gene programs in H3.3K27M DIPG

This study shows that H3.3K27M mutation disrupts lamina-associated domain organization, leading to activation of neuronal gene programs in DIPG.

Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain

The paper investigates the substructure and maturation of lamina-associated domains (LADs) in postmitotic neurons across human brain development, revealing dynamic changes in T1 and T2 LADs.

Sex-specific role for the long noncoding RNA Pnky in mouse behavior

This study shows that the lncRNA Pnky has sex-specific effects on mouse behavior, with male and female knockout mice displaying distinct behavioral deficits that can be reversed by a transgenic Pnky expression.

Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis

This study shows that spatial genome organization in human neurogenesis affects bivalent chromatin activity by relocating genes from the nuclear lamina to speckles, increasing transcription and resolving chromatin states.

Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus

This study shows that Kdm6b is essential for establishing and maintaining neural stem cells in the mouse hippocampus, with loss of Kdm6b leading to defective neurogenesis and cognitive impairments.