Daniel A. Lim

This study shows that H3.3K27M mutation disrupts lamina-associated domain organization, leading to activation of neuronal gene programs in DIPG.

The paper determines the structure of lncRNA Pnky and identifies structured regions involved in neural stem cell differentiation.

This study identifies B2 cells as the primary neural stem cells in the adult mouse V-SVZ, replacing B1 cells postnatally to sustain neurogenesis.

Nucleotide GPT predicts nuclear subcompartment-associated genome architecture from DNA sequence using a transformer model, achieving high accuracy for lamina and speckle-associated domains.

The paper investigates the substructure and maturation of lamina-associated domains (LADs) in postmitotic neurons across human brain development, revealing dynamic changes in T1 and T2 LADs.

This study uses in vivo perturb-seq to analyze gene function and radiotherapy responses in glioblastoma by targeting cancer and microenvironment cells.

This study shows that the lncRNA Pnky has sex-specific effects on mouse behavior, with male and female knockout mice displaying distinct behavioral deficits that can be reversed by a transgenic Pnky expression.

This study shows that spatial genome organization in human neurogenesis affects bivalent chromatin activity by relocating genes from the nuclear lamina to speckles, increasing transcription and resolving chromatin states.

This study shows that Kdm6b is essential for establishing and maintaining neural stem cells in the mouse hippocampus, with loss of Kdm6b leading to defective neurogenesis and cognitive impairments.

The paper uses single-cell and single nucleus sequencing to identify two distinct adult neurogenic lineages in the mouse V-SVZ, marked by specific gene expression patterns.