Mitchel A. Cole

This study shows that H3.3K27M mutation disrupts lamina-associated domain organization, leading to activation of neuronal gene programs in DIPG.

This study shows that spatial genome organization in human neurogenesis affects bivalent chromatin activity by relocating genes from the nuclear lamina to speckles, increasing transcription and resolving chromatin states.

This study identifies ZNF410 as a novel repressor of fetal globin by targeting the NuRD complex, offering a new therapeutic target for beta-hemoglobinopathies.

CRISPResso2 is a software tool for analyzing genome editing data, providing allele-specific quantification and scalable alignment to assess editing efficiency and safety.

CRISPR-SURF deconvolves CRISPR tiling screen data to identify functional regulatory elements across CRISPR-Cas, CRISPRi, and CRISPRa experiments.

CRISPRO maps guide RNA functional scores to genomic and structural coordinates, enabling structure-function relationship analysis and improved guide RNA efficacy prediction.