Sergei A. Grigoryev

This study uses molecular dynamics and cryo-ET to show histone tails drive chromatin compaction through specific interactions, revealing their role in both structural organization and nucleosome communication.

The paper investigates chromatin structure in immature and mature mouse retina cells, finding that short DNA linkers disrupt the two-start zigzag folding, leading to less compact chromatin in immature cells.

The paper trains segmentation networks for cryo-ET data using synthetic and real data, showing that synthetic data with molecular diversity improves performance but real data is needed for generalization.

This study uses cryo-ET to reveal novel chromatin folding motifs in native human chromatin and shows how histone citrullination affects nucleosome stacking and self-association.

The paper experimentally tests predictions about DNA topology in nucleosome arrays, showing linker length affects DNA linking number and topological structure.