Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT
Duneia McManus, Sabrina N. Copsel, Brent J. Pfeiffer, Dietlinde Wolf, Henry Barreras, Symon Ma, Ali Khodor, Seitaro Komai, Marina Burgos da Silva, Hajar Hazime, Miguel Gallardo, Sarah Grace R Lime, Marcel R.M. van den Brink, Jung‐Hyun Park, Maria T. Abreu, , Robert B. Levy
This paper shows that pretransplant targeting of TNFRSF25 and CD25 with a TL1A-Ig fusion protein and low-dose IL-2 expands recipient Tregs, reducing GVHD after HSCT while preserving GVL.
Blood · Aug 1, 2025Peer-reviewedImmunology