Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly
Shuai Qiao, Christine Langlois, Jakub Chrustowicz, Dawafuti Sherpa, Özge Karayel, Fynn M. Hansen, Viola Beier, Susanne von Gronau, Daniel Bollschweiler, Tillman Schäfer, Arno F. Alpi, Matthias Mann, Jesuraj Rajan Prabu, Brenda Arlene Schulman
The paper reveals how environmental changes trigger structural transitions in GID E3 ubiquitin ligase complexes, enabling substrate recognition and degradation.
Molecular Cell · Nov 7, 2019Peer-reviewedMolecular Biology