Fynn M. Hansen

The paper determines the structural context of PTMs across the human proteome and identifies regulatory sites by analyzing their distribution in folded and disordered regions.

AlphaMap visually annotates proteomics data with sequence-specific knowledge, enabling integration of experimental results with UniProt annotations and proteolytic cleavage sites.

The paper introduces a method to identify covalent modifications and protein interactions regulating immune signaling complex composition and function in monocytes.

Concurrent multi-omics of SARS-CoV-2 and SARS-CoV in A549 cells, integrated by network diffusion, maps shared and virus-specific host perturbations and nominates antiviral drug hotspots.

The paper develops a DIA-based workflow for ubiquitinome analysis, revealing circadian regulation through novel ubiquitination sites and clusters.

The paper reveals how environmental changes trigger structural transitions in GID E3 ubiquitin ligase complexes, enabling substrate recognition and degradation.