This study determines the molecular mechanism of M1-mediated influenza A virus assembly by analyzing M1's conformational states and interactions in virions.

bioRxiv · Apr 27, 2026 · PreprintMicrobiology

Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways

Kelsey L. Hickey, Alexandra Panov, Enya Miguel Whelan, Tillman Schäfer, Arda Mizrak, Ron R. Kopito, Wolfgang P. Baumeister, Rubén Fernández‐Busnadiego, J. Wade Harper

This study identifies UBE3C and NRF1-dependent proteasomal pathways that regulate acute protein aggregate turnover in response to misfolded protein accumulation.

Proceedings of the National Academy of Sciences · Dec 5, 2024Peer-reviewedCell Biology

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

Shuai Qiao, Christine Langlois, Jakub Chrustowicz, Dawafuti Sherpa, Özge Karayel, Fynn M. Hansen, Viola Beier, Susanne von Gronau, Daniel Bollschweiler, Tillman Schäfer, Arno F. Alpi, Matthias Mann, Jesuraj Rajan Prabu, Brenda Arlene Schulman

The paper reveals how environmental changes trigger structural transitions in GID E3 ubiquitin ligase complexes, enabling substrate recognition and degradation.

Molecular Cell · Nov 7, 2019Peer-reviewedMolecular Biology