Author

Jakub Chrustowicz

Max Planck Institute of BiochemistryORCID 0000-0002-3059-1863Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Organism:yeast· 1

Frequent Co-Authors

Brenda Arlene SchulmaniD· 3 shared Sara Sepic· 2 shared Susanne von Gronau· 2 shared Arno F. AlpiiD· 1 shared Benjamin L. EbertiD· 1 shared Christine LangloisiD· 1 shared Daniel BollschweileriD· 1 shared Dawafuti SherpaiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Brenda Arlene SchulmanORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 16, 2026

Multimodal substrate recruitment enables CTLH-MKLN1 E3 ligase to target N-, C-, and internal degrons

Sara Sepic, Karthik V Gottemukkala, Jiale Du…·Brenda Arlene Schulman

This study reveals how MKLN1's discoidin and Kelch domains recognize diverse degrons through multivalent interactions, enabling substrate recruitment by the CTLH-MKLN1 E3 ligase.

DOI 10.64898/2026.09.10.750665

experimental assay

BiochemistryNature Chemical BiologyPeer-reviewedApr 6, 2026

Charged Molecular Glue Discovery Enabled by Targeted Degron Display

Zhe Zhuang, Woong Sub Byun, Jakub Chrustowicz…·Nathanael S. Gray

The paper discovers a charged molecular glue, c-Glue, through targeted degron display, enabling the development of Molecular Glue Degraders (MGDs) for protein degradation.

11 citationstop 4%

humanproteomics

Molecular BiologyMolecular CellPeer-reviewedNov 7, 2019

Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

Shuai Qiao, Christine Langlois, Jakub Chrustowicz…·Brenda Arlene Schulman

The paper reveals how environmental changes trigger structural transitions in GID E3 ubiquitin ligase complexes, enabling substrate recognition and degradation.

94 citationstop 4%

yeastproteomics