Maria Ninova

This study identifies NEIL2 as a regulator of RNA polymerase II dynamics that suppresses transcription replication conflicts in pancreatic cancer cells.

The paper identifies SUMOylation targets in Drosophila ovary, revealing its role in heterochromatin regulation and piRNA pathway function.

This study identifies Bonus, a Drosophila TIF1 homolog, as a repressor of tissue-specific genes through SUMOylation-dependent recruitment of repressive chromatin complexes.

The paper shows that the SUMO pathway represses interrupted rDNA units and regulates expression of intact rDNA in Drosophila melanogaster, reducing cell-to-cell heterogeneity.

This study shows that the bacterial Argonaute nuclease CbAgo uses DNA interference to cleave multicopy genetic elements like plasmids and transposons by generating small DNA guides through cooperation with repair machinery.

The paper shows that Su(var)2-10 regulates gene expression in euchromatin and heterochromatin by establishing H3K9me3 and providing negative feedback.

This study shows that SUMO and Su(var)2-10 are required for piRNA-guided chromatin silencing in Drosophila by linking target recognition to histone methyltransferase recruitment.