Sergei S. Ryazansky

Dora, a key component of target-directed miRNA degradation, is essential for local genomic amplification in Drosophila ovarian follicle cells

This study identifies Dora as essential for chorion gene amplification and eggshell formation in Drosophila ovarian follicle cells through its role in the TDMD pathway.

Evidence of target-mediated miRNA degradation in Drosophila ovarian cell culture

The paper investigates target-mediated miRNA degradation (TDMD) in Drosophila ovarian cells, showing that Dora, the Drosophila ortholog of ZSWIM8, mediates miRNA degradation and affects Notch signaling.

Bacterial Argonaute nucleases reveal different modes of DNA targeting in vitro and in vivo

This study investigates the DNA targeting mechanisms of five bacterial Argonaute proteins in vitro and in vivo, revealing their ability to cleave DNA and defend against bacteriophages.

Detection of the germline specific NAC protein paralog enriched by intrinsically disordered regions in Drosophila melanogaster

The paper identifies a germinal cell-specific NAC paralog in Drosophila with expanded intrinsically disordered regions and shows it can suppress the lethal effect of losing the ubiquitous NAC-β subunit.

pAgo-induced DNA interference protects bacteria from invader DNA

This study shows that the bacterial Argonaute nuclease CbAgo uses DNA interference to cleave multicopy genetic elements like plasmids and transposons by generating small DNA guides through cooperation with repair machinery.

Programmable DNA cleavage by Ago nucleases from mesophilic bacteria Clostridium butyricum and Limnothrix rosea

This study identifies two mesophilic prokaryotic Argonautes that function as DNA-guided DNA nucleases at physiological temperatures, expanding their potential for genomic applications.

The expanded universe of prokaryotic Argonaute proteins

This study expands the known diversity of prokaryotic Argonaute proteins by analyzing sequenced genomes and identifying new genes, revealing their potential roles in DNA processing and genome editing.

Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline

This study shows that piRNAs are essential for telomere chromatin maintenance and nuclear positioning in Drosophila germline, with implications for heterochromatic component stability.