Wenwei Zheng

Hydrophobic Patch Spacing Produces Nonmonotonic Compaction in Intrinsically Disordered Proteins

This study shows that hydrophobic patch spacing in IDPs leads to nonmonotonic compaction, depending on interaction strength and architecture.

Topological Entanglement in Intrinsically Disordered Proteins: Sequence, Structural, and Functional Determinants

The paper uses entanglement measures from knot theory to analyze sequence and structural features of intrinsically disordered proteins and identifies functionally enriched regions in entanglement space.

Residue-Specific Modulation of Aggregation-Associated Interactions bySpermine in Tau, α-Synuclein, and Aβ40

This study shows how spermine modulates aggregation of Tau, α-synuclein, and Aβ40 by residue-specific interactions, revealing that net charge alone cannot predict its effects.

Resolving Conformational Heterogeneity in IntrinsicallyDisordered Proteins via Experimentally Guided Multi-Replica Simulations

The paper introduces MARS, a simulation framework that resolves conformational heterogeneity in IDPs by integrating experimental data from SAXS and PRE, revealing two major states in ER-NTD.

Transient Non-local Interactions Dominate the Dynamics of Measles Virus NTAIL

The paper identifies transient non-local interactions in measles virus NTAIL that dominate its dynamics and regulate conformational preferences and function.

Structural and Functional Relevance of Charge Based Transient Interactions inside Intrinsically Disordered Proteins

This study quantifies charge-based transient interactions in intrinsically disordered proteins, showing they shape conformational behavior and are enriched in specific biological functions.

Phase Separation to Resolve Growth-Related Circuit Failures

This paper introduces a method using liquid-liquid phase separation to stabilize synthetic gene circuits against growth fluctuations by maintaining local transcription factor concentration.

Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions

This study investigates how salt concentration affects the phase separation and aggregation of alpha-synuclein, revealing distinct salt dependencies and dynamic transitions between assembly states.