Generation of a PARPi-sensitive homozygous BRCA1-methylated OVCAR8 cell line using targeted CRISPR gene editing
Ksenija Nesic, Sally Beard, Lijun Xu, Olga Kondrashova, Cassandra J. Vandenberg, Alan F. Rubin, Fan Zhang, Alexander Dobrovic, Nicola Waddell, Clare L. Scott, Kristy Shield‐Artin, Matthew J. Wakefield
The paper generates a homozygous BRCA1-methylated OVCAR8 cell line using CRISPR editing to study meBRCA1 stability and PARPi resistance.
bioRxiv · Sep 23, 2024 · PreprintCancer Biology