Christian Schmidt

This paper introduces a cell-based system for propagating and quantifying human prion infectivity using CAD5 cells expressing human prion protein, demonstrating its effectiveness and therapeutic potential.

This study identifies syntaxin-6 as a modifier of prion and tau pathogenesis, showing it affects disease onset but not progression in experimental models.

The paper identifies key amino acids in Charge Cluster 2 of the prion protein critical for prion propagation across multiple strains.

This study uses single-nuclei transcriptomics to identify dynamic gene signatures in prion diseases across species.